2nz7
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2nz7 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2nz7 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NOD1_HUMAN NOD1_HUMAN]] Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.<ref>PMID:11058605</ref> <ref>PMID:19043560</ref> <ref>PMID:22672233</ref> <ref>PMID:17054981</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Dubas, R L | + | [[Category: Dubas, R L]] |
| - | [[Category: Park, Y C | + | [[Category: Park, Y C]] |
| - | [[Category: Robbins, S L | + | [[Category: Robbins, S L]] |
| - | [[Category: Thiagarajan, S | + | [[Category: Thiagarajan, S]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Disulfide bond]] | [[Category: Disulfide bond]] | ||
[[Category: Helix swapped]] | [[Category: Helix swapped]] | ||
Revision as of 07:12, 25 December 2014
Crystal Structure Analysis of Caspase-recruitment Domain (CARD) of Nod1
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