4czz
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czz RCSB], [http://www.ebi.ac.uk/pdbsum/4czz PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref> [[http://www.uniprot.org/uniprot/RCOR3_HUMAN RCOR3_HUMAN]] May act as a component of a corepressor complex that represses transcription (Potential). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Andres, M E | + | [[Category: Andres, M E]] |
| - | [[Category: Barrios, A P | + | [[Category: Barrios, A P]] |
| - | [[Category: Battaglioli, E | + | [[Category: Battaglioli, E]] |
| - | [[Category: Ciossani, G | + | [[Category: Ciossani, G]] |
| - | [[Category: Gomez, A V | + | [[Category: Gomez, A V]] |
| - | [[Category: Mattevi, A | + | [[Category: Mattevi, A]] |
| - | [[Category: Saez, J E | + | [[Category: Saez, J E]] |
| - | [[Category: Toffolo, E | + | [[Category: Toffolo, E]] |
[[Category: Corest]] | [[Category: Corest]] | ||
[[Category: Hdac1/2]] | [[Category: Hdac1/2]] | ||
Revision as of 07:12, 25 December 2014
Histone demethylase LSD1(KDM1A)-CoREST3 Complex
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Categories: Andres, M E | Barrios, A P | Battaglioli, E | Ciossani, G | Gomez, A V | Mattevi, A | Saez, J E | Toffolo, E | Corest | Hdac1/2 | Lsd1 | Oxidoreductase | Rcor2 | Rcor3
