2bpa
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bpa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_phix174 Enterobacteria phage phix174]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BPA FirstGlance]. <br> | <table><tr><td colspan='2'>[[2bpa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_phix174 Enterobacteria phage phix174]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BPA FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bpa RCSB], [http://www.ebi.ac.uk/pdbsum/2bpa PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bpa RCSB], [http://www.ebi.ac.uk/pdbsum/2bpa PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VGJ_BPPHX VGJ_BPPHX]] Mediates ssDNA packaging into virion, it locates to the internal surface of the capsid, thereby displacing the internal scaffolding protein B during virion formation. Additionally, protein J plays a role in viral attachment to the host cell. [[http://www.uniprot.org/uniprot/VGG_BPPHX VGG_BPPHX]] Attaches the circulating virion to the bacterial lipopolysaccharides which serve as receptor for the virus. Determines the phage host-range. Probably triggers with protein H the injection of the phage DNA into the host cytoplasm upon conformational changes induced by the interaction with host lipopolysaccharides.<ref>PMID:10739948</ref> <ref>PMID:14553915</ref> [[http://www.uniprot.org/uniprot/VGF_BPPHX VGF_BPPHX]] Assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins F.<ref>PMID:11991963</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Enterobacteria phage phix174]] | [[Category: Enterobacteria phage phix174]] | ||
| - | [[Category: Baker, T S | + | [[Category: Baker, T S]] |
| - | [[Category: Ilag, L L | + | [[Category: Ilag, L L]] |
| - | [[Category: Incardona, N L | + | [[Category: Incardona, N L]] |
| - | [[Category: Krishnaswamy, S | + | [[Category: Krishnaswamy, S]] |
| - | [[Category: McKenna, R | + | [[Category: McKenna, R]] |
| - | [[Category: Olson, N H | + | [[Category: Olson, N H]] |
| - | [[Category: Rossmann, M G | + | [[Category: Rossmann, M G]] |
| - | [[Category: Willingmann, P | + | [[Category: Willingmann, P]] |
| - | [[Category: Xia, D | + | [[Category: Xia, D]] |
[[Category: Icosahedral virus]] | [[Category: Icosahedral virus]] | ||
[[Category: Protein-dna complex]] | [[Category: Protein-dna complex]] | ||
[[Category: Single strand]] | [[Category: Single strand]] | ||
[[Category: Virus-dna complex]] | [[Category: Virus-dna complex]] | ||
Revision as of 07:15, 25 December 2014
ATOMIC STRUCTURE OF SINGLE-STRANDED DNA BACTERIOPHAGE PHIX174 AND ITS FUNCTIONAL IMPLICATIONS
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