2c62

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[[Image:2c62.gif|left|200px]]<br /><applet load="2c62" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2c62.gif|left|200px]]
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caption="2c62, resolution 1.74&Aring;" />
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'''CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA'''<br />
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{{Structure
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|PDB= 2c62 |SIZE=350|CAPTION= <scene name='initialview01'>2c62</scene>, resolution 1.74&Aring;
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2C62 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C62 OCA].
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2C62 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C62 OCA].
==Reference==
==Reference==
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A global transcription cofactor bound to juxtaposed strands of unwound DNA., Werten S, Moras D, Nat Struct Mol Biol. 2006 Feb;13(2):181-2. Epub 2006 Jan 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16415882 16415882]
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A global transcription cofactor bound to juxtaposed strands of unwound DNA., Werten S, Moras D, Nat Struct Mol Biol. 2006 Feb;13(2):181-2. Epub 2006 Jan 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16415882 16415882]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transcription regulation]]
[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:45:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:11:15 2008''

Revision as of 14:11, 20 March 2008

Image:2c62.gif


PDB ID 2c62

Drag the structure with the mouse to rotate
, resolution 1.74Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA


Overview

The 1.74-A crystal structure of the human transcription cofactor PC4 in complex with a single-stranded 20-mer oligonucleotide reveals how symmetry-related beta-surfaces of the protein homodimer interact with juxtaposed 5-nucleotide DNA regions running in opposite directions. The structure explains high-affinity binding of PC4 to the complementary strands of unwinding duplex DNA, and it suggests the cofactor may have a role in relaxing negative supercoils or exposing unpaired bases for sequence-specific recognition by other biomolecules.

About this Structure

2C62 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A global transcription cofactor bound to juxtaposed strands of unwound DNA., Werten S, Moras D, Nat Struct Mol Biol. 2006 Feb;13(2):181-2. Epub 2006 Jan 15. PMID:16415882

Page seeded by OCA on Thu Mar 20 16:11:15 2008

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