2c6a

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[[Image:2c6a.gif|left|200px]]<br /><applet load="2c6a" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2c6a.gif|left|200px]]
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caption="2c6a" />
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'''SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2'''<br />
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{{Structure
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|PDB= 2c6a |SIZE=350|CAPTION= <scene name='initialview01'>2c6a</scene>
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2C6A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6A OCA].
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2C6A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6A OCA].
==Reference==
==Reference==
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Solution structure of the C4 zinc finger domain of HDM2., Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M, Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16385008 16385008]
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Solution structure of the C4 zinc finger domain of HDM2., Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M, Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16385008 16385008]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc finger]]
[[Category: zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:45:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:11:27 2008''

Revision as of 14:11, 20 March 2008

Image:2c6a.gif


PDB ID 2c6a

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Ligands:
Coordinates: save as pdb, mmCIF, xml



SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2


Overview

HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.

About this Structure

2C6A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the C4 zinc finger domain of HDM2., Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M, Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:16385008

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