4qd2

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dong, M.]]
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[[Category: Dong, M]]
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[[Category: Dorner, M B.]]
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[[Category: Dorner, M B]]
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[[Category: Gu, S.]]
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[[Category: Gu, S]]
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[[Category: Jin, R.]]
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[[Category: Jin, R]]
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[[Category: Kruel, A.]]
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[[Category: Kruel, A]]
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[[Category: Lee, K.]]
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[[Category: Lee, K]]
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[[Category: Perry, K.]]
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[[Category: Perry, K]]
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[[Category: Rummel, A.]]
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[[Category: Rummel, A]]
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[[Category: Zhong, X.]]
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[[Category: Zhong, X]]
[[Category: Botulinum neurotoxin]]
[[Category: Botulinum neurotoxin]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]

Revision as of 07:30, 25 December 2014

Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex

4qd2, resolution 2.40Å

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