2wjz

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wjz RCSB], [http://www.ebi.ac.uk/pdbsum/2wjz PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wjz RCSB], [http://www.ebi.ac.uk/pdbsum/2wjz PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HIS6_THEMA HIS6_THEMA]] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.[HAMAP-Rule:MF_01013] [[http://www.uniprot.org/uniprot/HIS5_THEMA HIS5_THEMA]] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.[HAMAP-Rule:MF_00278]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Babinger, K.]]
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[[Category: Babinger, K]]
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[[Category: Haeger, M C.]]
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[[Category: Haeger, M C]]
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[[Category: Kuper, J.]]
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[[Category: Kuper, J]]
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[[Category: List, F.]]
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[[Category: List, F]]
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[[Category: Razeto, A.]]
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[[Category: Razeto, A]]
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[[Category: Sterner, R.]]
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[[Category: Sterner, R]]
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[[Category: Vega, M C.]]
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[[Category: Vega, M C]]
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[[Category: Wilmanns, M.]]
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[[Category: Wilmanns, M]]
[[Category: Amino-acid biosynthesis]]
[[Category: Amino-acid biosynthesis]]
[[Category: Ammonia channel]]
[[Category: Ammonia channel]]

Revision as of 07:37, 25 December 2014

Crystal structure of (HisH) K181A Y138A mutant of imidazoleglycerolphosphate synthase (HisH HisF) which displays constitutive glutaminase activity

2wjz, resolution 2.60Å

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