1m18
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1m18]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M18 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1m18]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M18 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1SZ:N-[5-[[4-[[5-[[5-[[5-[[5-[[3-[3-(DIMETHYLAMINO)PROPYLAMINO]-3-OXIDANYLIDENE-PROPYL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]AMINO]-4-OXIDANYLIDENE-BUTYL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]-1-METHYL-4-[[1-METHYL-4-[(1-METHYLIMIDAZOL-2-YL)CARBONYLAMINO]PYRROL-2-YL]CARBONYLAMINO]IMIDAZOLE-2-CARBOXAMIDE'>1SZ</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1SZ:N-[5-[[4-[[5-[[5-[[5-[[5-[[3-[3-(DIMETHYLAMINO)PROPYLAMINO]-3-OXIDANYLIDENE-PROPYL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]AMINO]-4-OXIDANYLIDENE-BUTYL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]-1-METHYL-4-[[1-METHYL-4-[(1-METHYLIMIDAZOL-2-YL)CARBONYLAMINO]PYRROL-2-YL]CARBONYLAMINO]IMIDAZOLE-2-CARBOXAMIDE'>1SZ</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aoi|1aoi]], [[1m19|1m19]], [[1m1a|1m1a]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aoi|1aoi]], [[1m19|1m19]], [[1m1a|1m1a]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m18 RCSB], [http://www.ebi.ac.uk/pdbsum/1m18 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m18 RCSB], [http://www.ebi.ac.uk/pdbsum/1m18 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
| - | [[Category: Dervan, P B | + | [[Category: Dervan, P B]] |
| - | [[Category: Edayathumangalam, R S | + | [[Category: Edayathumangalam, R S]] |
| - | [[Category: Gottesfeld, J M | + | [[Category: Gottesfeld, J M]] |
| - | [[Category: Luger, K | + | [[Category: Luger, K]] |
| - | [[Category: Melander, C | + | [[Category: Melander, C]] |
| - | [[Category: Suto, R K | + | [[Category: Suto, R K]] |
| - | [[Category: White, C L | + | [[Category: White, C L]] |
[[Category: Chromatin]] | [[Category: Chromatin]] | ||
[[Category: Chromatin remodeling]] | [[Category: Chromatin remodeling]] | ||
Revision as of 07:48, 25 December 2014
LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
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