4bm8
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bm8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BM8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4bm8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BM8 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A6J:(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-B-D-GALACTOPYRANOSYL)-(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-2-O-SULFO-B-D-GALACTOPYRANOSYL)-SULFIDE'>A6J</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A6J:(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-B-D-GALACTOPYRANOSYL)-(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-2-O-SULFO-B-D-GALACTOPYRANOSYL)-SULFIDE'>A6J</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bli|4bli]], [[4blj|4blj]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bli|4bli]], [[4blj|4blj]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4bm8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4bm8 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Engstrom, O | + | [[Category: Engstrom, O]] |
| - | [[Category: Hakansson, M | + | [[Category: Hakansson, M]] |
| - | [[Category: Leffler, H | + | [[Category: Leffler, H]] |
| - | [[Category: Logan, D T | + | [[Category: Logan, D T]] |
| - | [[Category: Nilsson, U J | + | [[Category: Nilsson, U J]] |
| - | [[Category: Noresson, A L | + | [[Category: Noresson, A L]] |
| - | [[Category: Oberg, C T | + | [[Category: Oberg, C T]] |
[[Category: Ige-binding protein]] | [[Category: Ige-binding protein]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 07:50, 25 December 2014
Galectin-3c in complex with Bisamido-thiogalactoside derivate 3
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