2c9n

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[[Image:2c9n.gif|left|200px]]<br /><applet load="2c9n" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2c9n.gif|left|200px]]
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caption="2c9n, resolution 3.3&Aring;" />
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'''STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION'''<br />
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{{Structure
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|PDB= 2c9n |SIZE=350|CAPTION= <scene name='initialview01'>2c9n</scene>, resolution 3.3&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2C9N is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9N OCA].
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2C9N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9N OCA].
==Reference==
==Reference==
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Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein., Petosa C, Morand P, Baudin F, Moulin M, Artero JB, Muller CW, Mol Cell. 2006 Feb 17;21(4):565-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16483937 16483937]
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Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein., Petosa C, Morand P, Baudin F, Moulin M, Artero JB, Muller CW, Mol Cell. 2006 Feb 17;21(4):565-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16483937 16483937]
[[Category: Human herpesvirus 4]]
[[Category: Human herpesvirus 4]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: zta]]
[[Category: zta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:46:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:12:41 2008''

Revision as of 14:12, 20 March 2008

Image:2c9n.gif


PDB ID 2c9n

Drag the structure with the mouse to rotate
, resolution 3.3Å
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION


Overview

Epstein-Barr virus (EBV) causes infectious mononucleosis and is linked to several human malignancies. EBV has a biphasic infection cycle consisting of a latent and a lytic, replicative phase. The switch from latent to lytic infection is triggered by the EBV immediate-early transcription factor ZEBRA (BZLF1, Zta, Z, EB1). We present the crystal structure of ZEBRA's DNA binding domain bound to an EBV lytic gene promoter element. ZEBRA exhibits a variant of the basic-region leucine zipper (bZIP) fold in which a C-terminal moiety stabilizes the coiled coil involved in dimer formation. The structure provides insights into ZEBRA's broad target site specificity, preferential activation of specific EBV promoters in their methylated state, ability to dimerize despite lacking a leucine zipper motif, and failure to heterodimerize with cellular bZIP proteins. The structure will allow for the design of new therapeutic agents that block activation of the EBV lytic cycle.

About this Structure

2C9N is a Protein complex structure of sequences from Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein., Petosa C, Morand P, Baudin F, Moulin M, Artero JB, Muller CW, Mol Cell. 2006 Feb 17;21(4):565-72. PMID:16483937

Page seeded by OCA on Thu Mar 20 16:12:41 2008

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