1wa9
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1wa9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WA9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WA9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1wa9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WA9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WA9 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wa9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wa9 RCSB], [http://www.ebi.ac.uk/pdbsum/1wa9 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wa9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wa9 RCSB], [http://www.ebi.ac.uk/pdbsum/1wa9 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PER_DROME PER_DROME]] Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: Berndt, A | + | [[Category: Berndt, A]] |
| - | [[Category: Cardone, L | + | [[Category: Cardone, L]] |
| - | [[Category: Doi, M | + | [[Category: Doi, M]] |
| - | [[Category: Hennig, S | + | [[Category: Hennig, S]] |
| - | [[Category: Sassone-Corsi, P | + | [[Category: Sassone-Corsi, P]] |
| - | [[Category: Schulze, S | + | [[Category: Schulze, S]] |
| - | [[Category: Urbanke, C | + | [[Category: Urbanke, C]] |
| - | [[Category: Wolf, E | + | [[Category: Wolf, E]] |
| - | [[Category: Yildiz, O | + | [[Category: Yildiz, O]] |
| - | [[Category: Yujnovsky, I | + | [[Category: Yujnovsky, I]] |
[[Category: Circadian rhythm]] | [[Category: Circadian rhythm]] | ||
[[Category: Clock protein]] | [[Category: Clock protein]] | ||
Revision as of 07:57, 25 December 2014
CRYSTAL STRUCTURE OF THE PAS REPEAT REGION OF THE DROSOPHILA CLOCK PROTEIN PERIOD
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