4iim
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iim RCSB], [http://www.ebi.ac.uk/pdbsum/4iim PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iim RCSB], [http://www.ebi.ac.uk/pdbsum/4iim PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:13, 25 December 2014
Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide
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Categories: Homo sapiens | Arrowsmith, C H | Bountra, C | Dong, A | Edwards, A M | Gu, J | Guan, X | Huang, H | Structural genomic | Sidhu, S | Tong, Y | Wernimont, A | Endocytosis | Itsn1 | Protein-peptide complex | Sgc | Sh3 domain
