2ajm
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ajm]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJM FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ajm]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJM FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ajj|2ajj]], [[2ajn|2ajn]], [[2ajo|2ajo]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ajj|2ajj]], [[2ajn|2ajn]], [[2ajo|2ajo]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ajm RCSB], [http://www.ebi.ac.uk/pdbsum/2ajm PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ajm RCSB], [http://www.ebi.ac.uk/pdbsum/2ajm PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/POLG_BVDVC POLG_BVDVC]] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity). P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity). Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus. NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Brass, V | + | [[Category: Brass, V]] |
| - | [[Category: Chipot, C | + | [[Category: Chipot, C]] |
| - | [[Category: Deleage, G | + | [[Category: Deleage, G]] |
| - | [[Category: Montserret, R | + | [[Category: Montserret, R]] |
| - | [[Category: Moradpour, D | + | [[Category: Moradpour, D]] |
| - | [[Category: Penin, F | + | [[Category: Penin, F]] |
| - | [[Category: Sapay, N | + | [[Category: Sapay, N]] |
[[Category: Amphipathic alpha-helix]] | [[Category: Amphipathic alpha-helix]] | ||
[[Category: In-plane membrane anchor domain]] | [[Category: In-plane membrane anchor domain]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
Revision as of 08:18, 25 December 2014
NMR structure of the in-plane membrane anchor domain [1-28] of the monotopic NonStructural Protein 5A (NS5A) from the Bovine Viral Diarrhea Virus (BVDV)
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