2cde

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[[Image:2cde.gif|left|200px]]<br /><applet load="2cde" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2cde.gif|left|200px]]
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caption="2cde, resolution 3.5&Aring;" />
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'''STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE SPECIFIC T CELL RECEPTORS-INKT-TCR'''<br />
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{{Structure
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|PDB= 2cde |SIZE=350|CAPTION= <scene name='initialview01'>2cde</scene>, resolution 3.5&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE SPECIFIC T CELL RECEPTORS-INKT-TCR'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2CDE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDE OCA].
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2CDE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDE OCA].
==Reference==
==Reference==
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Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors., Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY, J Exp Med. 2006 Mar 20;203(3):699-710. Epub 2006 Mar 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16520393 16520393]
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Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors., Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY, J Exp Med. 2006 Mar 20;203(3):699-710. Epub 2006 Mar 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16520393 16520393]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tcr]]
[[Category: tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:47:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:14:02 2008''

Revision as of 14:14, 20 March 2008

Image:2cde.gif


PDB ID 2cde

Drag the structure with the mouse to rotate
, resolution 3.5Å
Coordinates: save as pdb, mmCIF, xml



STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE SPECIFIC T CELL RECEPTORS-INKT-TCR


Overview

Invariant human TCR Valpha24-Jalpha18+/Vbeta11+ NKT cells (iNKT) are restricted by CD1d-alpha-glycosylceramides. We analyzed crystal structures and binding characteristics for an iNKT TCR plus two CD1d-alpha-GalCer-specific Vbeta11+ TCRs that use different TCR Valpha chains. The results were similar to those previously reported for MHC-peptide-specific TCRs, illustrating the versatility of the TCR platform. Docking TCR and CD1d-alpha-GalCer structures provided plausible insights into their interaction. The model supports a diagonal orientation of TCR on CD1d and suggests that complementarity determining region (CDR)3alpha, CDR3beta, and CDR1beta interact with ligands presented by CD1d, whereas CDR2beta binds to the CD1d alpha1 helix. This docking provides an explanation for the dominant usage of Vbeta11 and Vbeta8.2 chains by human and mouse iNKT cells, respectively, for recognition of CD1d-alpha-GalCer.

About this Structure

2CDE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors., Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY, J Exp Med. 2006 Mar 20;203(3):699-710. Epub 2006 Mar 6. PMID:16520393

Page seeded by OCA on Thu Mar 20 16:14:02 2008

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