3kdg
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kdg RCSB], [http://www.ebi.ac.uk/pdbsum/3kdg PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kdg RCSB], [http://www.ebi.ac.uk/pdbsum/3kdg PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MUTL_BACSU MUTL_BACSU]] This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). Overexpression of mutSL partially suppresses the high spontaneous mutation frequency of a ytkD/mutM/yfhQ triple disruption which lacks the system required to prevent damage by oxidized guanine (8-oxo-dGTP). This suggests that MutSL also functions to repair mismatches due to oxidative stress in both growing and stationary phase cells.<ref>PMID:19011023</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 08:21, 25 December 2014
C-terminal domain of Bacillus subtilis MutL crystal form II
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