4c4f
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c4f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c4f RCSB], [http://www.ebi.ac.uk/pdbsum/4c4f PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c4f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c4f RCSB], [http://www.ebi.ac.uk/pdbsum/4c4f PDBsum]</span></td></tr> | ||
</table> | </table> | ||
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == |
Revision as of 08:44, 25 December 2014
Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
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Categories: Dual-specificity kinase | Human | Atrash, B | Baker, R | Bavetsias, V | Blagg, J | Boxall, K | Brandon, A de Haven | Burke, R | Choi, V | Eccles, S A | Faisal, A | Gurden, M | Hayes, A | Henley, A | Linardopoulos, S | Liu, M | Mak, G | Matijssen, B | McAndrew, C | Montfort, R van | Naud, S | Raynaud, F I | Schmitt, J | Sheldrake, P | Valenti, M | Westwood, I M | Wood, A | Mitosis | Protein kinase | Structure-based design | Transferase