1m11
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1m11]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_e7 Echovirus e7] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M11 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1m11]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_e7 Echovirus e7] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M11 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g40|1g40]], [[1cov|1cov]], [[1ev1|1ev1]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g40|1g40]], [[1cov|1cov]], [[1ev1|1ev1]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m11 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m11 RCSB], [http://www.ebi.ac.uk/pdbsum/1m11 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m11 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m11 RCSB], [http://www.ebi.ac.uk/pdbsum/1m11 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q914E0_9ENTO Q914E0_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047] [[http://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Echovirus e7]] | [[Category: Echovirus e7]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Baker, T S | + | [[Category: Baker, T S]] |
| - | [[Category: Bator, C M | + | [[Category: Bator, C M]] |
| - | [[Category: Chipman, P R | + | [[Category: Chipman, P R]] |
| - | [[Category: He, Y | + | [[Category: He, Y]] |
| - | [[Category: Kuhn, R J | + | [[Category: Kuhn, R J]] |
| - | [[Category: Lin, F | + | [[Category: Lin, F]] |
| - | [[Category: Medof, M E | + | [[Category: Medof, M E]] |
| - | [[Category: Rossmann, M G | + | [[Category: Rossmann, M G]] |
| - | [[Category: Shoham, M | + | [[Category: Shoham, M]] |
[[Category: Decay-accelerating factor]] | [[Category: Decay-accelerating factor]] | ||
[[Category: Icosahedral virus]] | [[Category: Icosahedral virus]] | ||
[[Category: Scr]] | [[Category: Scr]] | ||
[[Category: Virus-receptor complex]] | [[Category: Virus-receptor complex]] | ||
Revision as of 08:46, 25 December 2014
structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy
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