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3ld1
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ld1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ld1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ld1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ld1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ld1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ld1 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). The peptide p16 might be involved in the EGF signaling pathway (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:54, 25 December 2014
Crystal Structure of IBV Nsp2a
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Categories: Viruses | Bartlam, M | Chen, C | Cong, L | Fu, J | Rao, Z | Tang, H | Wei, L | Xu, Y | Yang, A | Globular like | Host cytoplasm | Host membrane | Hydrolase | Membrane | Metal-binding | Protease | Rna-binding | Thiol protease | Transmembrane | Zinc-finger
