1gd2

From Proteopedia

(Difference between revisions)

Revision as of 08:58, 25 December 2014

CRYSTAL STRUCTURE OF BZIP TRANSCRIPTION FACTOR PAP1 BOUND TO DNA

Structural highlights

1gd2 is a 10 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[AP1_SCHPO] Required for SPK1-confered staurosporine resistance. Can confer resistance alone in high levels. Transcriptional activator that recognizes the 5'-TGACTCA-3' sequence element common in GN4/AP-1 sites.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The basic region leucine zipper (bZIP) proteins form one of the largest families of transcription factors in eukaryotic cells. Despite relatively high homology between the amino acid sequences of the bZIP motifs, these proteins recognize diverse DNA sequences. Here we report the 2.0 A resolution crystal structure of the bZIP motif of one such transcription factor, PAP1, a fission yeast AP-1-like transcription factor that binds DNA containing the novel consensus sequence TTACGTAA. The structure reveals how the Pap1-specific residues of the bZIP basic region recognize the target sequence and shows that the side chain of the invariant Asn in the bZIP motif adopts an alternative conformation in Pap1. This conformation, which is stabilized by a Pap1-specific residue and its associated water molecule, recognizes a different base in the target sequence from that in other bZIP subfamilies.

Structural basis for the diversity of DNA recognition by bZIP transcription factors.,Fujii Y, Shimizu T, Toda T, Yanagida M, Hakoshima T Nat Struct Biol. 2000 Oct;7(10):889-93. PMID:11017199^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Fujii Y, Shimizu T, Toda T, Yanagida M, Hakoshima T. Structural basis for the diversity of DNA recognition by bZIP transcription factors. Nat Struct Biol. 2000 Oct;7(10):889-93. PMID:11017199 doi:10.1038/82822

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gd2"

@@ Line 5: / Line 5: @@
 </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gd2 RCSB], [http://www.ebi.ac.uk/pdbsum/1gd2 PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AP1_SCHPO AP1_SCHPO]] Required for SPK1-confered staurosporine resistance. Can confer resistance alone in high levels. Transcriptional activator that recognizes the 5'-TGACTCA-3' sequence element common in GN4/AP-1 sites.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1gd2

From Proteopedia

Revision as of 08:58, 25 December 2014

CRYSTAL STRUCTURE OF BZIP TRANSCRIPTION FACTOR PAP1 BOUND TO DNA

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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