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2l0a
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l0a RCSB], [http://www.ebi.ac.uk/pdbsum/2l0a PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l0a RCSB], [http://www.ebi.ac.uk/pdbsum/2l0a PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/STAM1_HUMAN STAM1_HUMAN]] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Acton, T B | + | [[Category: Acton, T B]] |
| - | [[Category: Ciccosanti, C | + | [[Category: Ciccosanti, C]] |
| - | [[Category: Everett, J K | + | [[Category: Everett, J K]] |
| - | [[Category: Janjua, H | + | [[Category: Janjua, H]] |
| - | [[Category: Montelione, G T | + | [[Category: Montelione, G T]] |
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[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
| + | [[Category: Rost, B]] | ||
| + | [[Category: Shastry, R]] | ||
| + | [[Category: Tang, Y]] | ||
| + | [[Category: Xiao, R]] | ||
| + | [[Category: PSI, Protein structure initiative]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 09:04, 25 December 2014
Solution NMR Structure of Signal transducing adapter molecule 1 STAM-1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4479E
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