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3qrx
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3qrx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlre Chlre]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRX FirstGlance]. <br> | <table><tr><td colspan='2'>[[3qrx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlre Chlre]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRX FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VFL2, CHLREDRAFT_159554 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 CHLRE])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VFL2, CHLREDRAFT_159554 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 CHLRE])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrx RCSB], [http://www.ebi.ac.uk/pdbsum/3qrx PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrx RCSB], [http://www.ebi.ac.uk/pdbsum/3qrx PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MEL_APIME MEL_APIME]] Melittin: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na(+)-K(+)-ATPase and the H(+)-K(+)-ATPase. It increases the permeability of cell membranes to ions, particularly Na(+) and indirectly Ca(2+), because of the Na(+)-Ca(2+)-exchange. It acts synergistically with phospholipase A2.<ref>PMID:20472009</ref> Melittin-S: 1.4-fold less hemolytic and adopts a less organized secondary structure than melittin.<ref>PMID:20472009</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 13: | Line 15: | ||
The structure, molecular dynamics, and energetics of centrin-melittin complex.,Sosa Ldel V, Alfaro E, Santiago J, Narvaez D, Rosado MC, Rodriguez A, Gomez AM, Schreiter ER, Pastrana-Rios B Proteins. 2011 Nov;79(11):3132-43. doi: 10.1002/prot.23142. Epub 2011 Aug, 30. PMID:21989934<ref>PMID:21989934</ref> | The structure, molecular dynamics, and energetics of centrin-melittin complex.,Sosa Ldel V, Alfaro E, Santiago J, Narvaez D, Rosado MC, Rodriguez A, Gomez AM, Schreiter ER, Pastrana-Rios B Proteins. 2011 Nov;79(11):3132-43. doi: 10.1002/prot.23142. Epub 2011 Aug, 30. PMID:21989934<ref>PMID:21989934</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 20: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Chlre]] | [[Category: Chlre]] | ||
| - | [[Category: Schreiter, E R | + | [[Category: Schreiter, E R]] |
[[Category: Calcium binding]] | [[Category: Calcium binding]] | ||
[[Category: Calcium-binding]] | [[Category: Calcium-binding]] | ||
Revision as of 09:07, 25 December 2014
Chlamydomonas reinhardtii centrin bound to melittin
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