4gu5
From Proteopedia
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| - | + | ==Structure of Full-length Drosophila Cryptochrome== | |
| - | === | + | <StructureSection load='4gu5' size='340' side='right' caption='[[4gu5]], [[Resolution|resolution]] 2.30Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4gu5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3tvs 3tvs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GU5 FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG3772, cry ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gu5 RCSB], [http://www.ebi.ac.uk/pdbsum/4gu5 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/CRY1_DROME CRY1_DROME]] Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.<ref>PMID:9845369</ref> <ref>PMID:10063806</ref> <ref>PMID:9845370</ref> <ref>PMID:10233998</ref> <ref>PMID:10417378</ref> <ref>PMID:16527739</ref> <ref>PMID:17298948</ref> <ref>PMID:18641630</ref> <ref>PMID:18597555</ref> | [[http://www.uniprot.org/uniprot/CRY1_DROME CRY1_DROME]] Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.<ref>PMID:9845369</ref> <ref>PMID:10063806</ref> <ref>PMID:9845370</ref> <ref>PMID:10233998</ref> <ref>PMID:10417378</ref> <ref>PMID:16527739</ref> <ref>PMID:17298948</ref> <ref>PMID:18641630</ref> <ref>PMID:18597555</ref> | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | + | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: Crane, B R | + | [[Category: Crane, B R]] |
| - | [[Category: Jones, A R | + | [[Category: Jones, A R]] |
| - | [[Category: Levy, C | + | [[Category: Levy, C]] |
| - | [[Category: Leys, D | + | [[Category: Leys, D]] |
| - | [[Category: Scrutton, N S | + | [[Category: Scrutton, N S]] |
| - | [[Category: Top, D | + | [[Category: Top, D]] |
| - | [[Category: Vaidya, A T | + | [[Category: Vaidya, A T]] |
| - | [[Category: Widom, J | + | [[Category: Widom, J]] |
| - | [[Category: Young, M W | + | [[Category: Young, M W]] |
| - | [[Category: Zoltowski, B D | + | [[Category: Zoltowski, B D]] |
[[Category: Circadian clock light entrainment]] | [[Category: Circadian clock light entrainment]] | ||
[[Category: Gene regulation]] | [[Category: Gene regulation]] | ||
Revision as of 09:09, 25 December 2014
Structure of Full-length Drosophila Cryptochrome
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Categories: Drosophila melanogaster | Crane, B R | Jones, A R | Levy, C | Leys, D | Scrutton, N S | Top, D | Vaidya, A T | Widom, J | Young, M W | Zoltowski, B D | Circadian clock light entrainment | Gene regulation | Jetlag | Phosphorylation | Photolyase | Protein degradation | Signaling protein | Timeless
