3a8q
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3a8q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A8Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[3a8q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A8Q FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a8n|3a8n]], [[3a8p|3a8p]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a8n|3a8n]], [[3a8p|3a8p]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a8q RCSB], [http://www.ebi.ac.uk/pdbsum/3a8q PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a8q RCSB], [http://www.ebi.ac.uk/pdbsum/3a8q PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TIAM2_MOUSE TIAM2_MOUSE]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.<ref>PMID:10364228</ref> <ref>PMID:11707441</ref> <ref>PMID:12912917</ref> <ref>PMID:14550769</ref> <ref>PMID:17320046</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 30: | Line 32: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Hakoshima, T | + | [[Category: Hakoshima, T]] |
| - | [[Category: Higuchi, Y | + | [[Category: Higuchi, Y]] |
| - | [[Category: Itoh, N | + | [[Category: Itoh, N]] |
| - | [[Category: Kaibuchi, K | + | [[Category: Kaibuchi, K]] |
| - | [[Category: Kitano, K | + | [[Category: Kitano, K]] |
| - | [[Category: Mori, T | + | [[Category: Mori, T]] |
| - | [[Category: Terawaki, S | + | [[Category: Terawaki, S]] |
| - | [[Category: Watanabe, T | + | [[Category: Watanabe, T]] |
| - | [[Category: Zhai, Y | + | [[Category: Zhai, Y]] |
[[Category: Cell projection]] | [[Category: Cell projection]] | ||
[[Category: Guanine nucleotide exchange factor]] | [[Category: Guanine nucleotide exchange factor]] | ||
Revision as of 09:10, 25 December 2014
Low-resolution crystal structure of the Tiam2 PHCCEx domain
| |||||||||||
