2odb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2odb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ODB FirstGlance]. <br>
<table><tr><td colspan='2'>[[2odb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ODB FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1grn|1grn]]</td></tr>
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1grn|1grn]]</td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC42 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC42 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2odb RCSB], [http://www.ebi.ac.uk/pdbsum/2odb PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2odb RCSB], [http://www.ebi.ac.uk/pdbsum/2odb PDBsum]</span></td></tr>
-
<table>
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref> [[http://www.uniprot.org/uniprot/PAK6_HUMAN PAK6_HUMAN]] Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.<ref>PMID:14573606</ref> <ref>PMID:20054820</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 22: Line 24:
*[[GTP-binding protein|GTP-binding protein]]
*[[GTP-binding protein|GTP-binding protein]]
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Arrowsmith, C]]
-
[[Category: Burgess, N.]]
+
[[Category: Burgess, N]]
-
[[Category: Debreczeni, J E.]]
+
[[Category: Debreczeni, J E]]
-
[[Category: Delft, F von.]]
+
[[Category: Delft, F von]]
-
[[Category: Doyle, D.]]
+
[[Category: Doyle, D]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards, A]]
-
[[Category: Elkins, J.]]
+
[[Category: Elkins, J]]
-
[[Category: Eswaran, J.]]
+
[[Category: Eswaran, J]]
-
[[Category: Gileadi, O.]]
+
[[Category: Gileadi, O]]
-
[[Category: Knapp, S.]]
+
[[Category: Knapp, S]]
-
[[Category: Pike, A C.W.]]
+
[[Category: Pike, A C.W]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Structural genomic]]
-
[[Category: Soundararajan, M.]]
+
[[Category: Soundararajan, M]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Sundstrom, M]]
-
[[Category: Ugochukwu, E.]]
+
[[Category: Ugochukwu, E]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt, J]]
-
[[Category: Yang, X.]]
+
[[Category: Yang, X]]
[[Category: Crib]]
[[Category: Crib]]
[[Category: Kinase]]
[[Category: Kinase]]
Line 48: Line 52:
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Small gtpase]]
[[Category: Small gtpase]]
-
[[Category: Structural genomic]]
 
-
[[Category: Structural genomics consortium]]
 

Revision as of 09:11, 25 December 2014

The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)

2odb, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2odb"
Personal tools