2cjp

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[[Image:2cjp.gif|left|200px]]<br /><applet load="2cjp" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2cjp.gif|left|200px]]
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caption="2cjp, resolution 1.95&Aring;" />
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'''STRUCTURE OF POTATO (SOLANUM TUBEROSUM) EPOXIDE HYDROLASE I (STEH1)'''<br />
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{{Structure
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|PDB= 2cjp |SIZE=350|CAPTION= <scene name='initialview01'>2cjp</scene>, resolution 1.95&Aring;
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|SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=VPR:2-PROPYLPENTANAMIDE'>VPR</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Transferred_entry:_3.3.2.9 Transferred entry: 3.3.2.9], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.3 3.3.2.3]
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|GENE=
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}}
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'''STRUCTURE OF POTATO (SOLANUM TUBEROSUM) EPOXIDE HYDROLASE I (STEH1)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2CJP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Solanum_tuberosum Solanum tuberosum] with <scene name='pdbligand=PG4:'>PG4</scene>, <scene name='pdbligand=VPR:'>VPR</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_3.3.2.9 Transferred entry: 3.3.2.9], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.3 3.3.2.3] Known structural/functional Site: <scene name='pdbsite=AC1:Edo+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJP OCA].
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2CJP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Solanum_tuberosum Solanum tuberosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJP OCA].
==Reference==
==Reference==
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X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes., Mowbray SL, Elfstrom LT, Ahlgren KM, Andersson CE, Widersten M, Protein Sci. 2006 Jul;15(7):1628-37. Epub 2006 Jun 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16751602 16751602]
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X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes., Mowbray SL, Elfstrom LT, Ahlgren KM, Andersson CE, Widersten M, Protein Sci. 2006 Jul;15(7):1628-37. Epub 2006 Jun 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16751602 16751602]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Solanum tuberosum]]
[[Category: Solanum tuberosum]]
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[[Category: hydrolase]]
[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:49:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:16:19 2008''

Revision as of 14:16, 20 March 2008

Image:2cjp.gif


PDB ID 2cjp

Drag the structure with the mouse to rotate
, resolution 1.95Å
Sites:
Ligands: , and
Activity: Transferred entry: 3.3.2.9, with EC number 3.3.2.3
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF POTATO (SOLANUM TUBEROSUM) EPOXIDE HYDROLASE I (STEH1)


Overview

Epoxide hydrolases catalyze the conversion of epoxides to diols. The known functions of such enzymes include detoxification of xenobiotics, drug metabolism, synthesis of signaling compounds, and intermediary metabolism. In plants, epoxide hydrolases are thought to participate in general defense systems. In the present study, we report the first structure of a plant epoxide hydrolase, one of the four homologous enzymes found in potato. The structure was solved by molecular replacement and refined to a resolution of 1.95 A. Analysis of the structure allows a better understanding of the observed substrate specificities and activity. Further, comparisons with mammalian and fungal epoxide hydrolase structures reported earlier show the basis of differing substrate specificities in the various epoxide hydrolase subfamilies. Most plant enzymes, like the potato epoxide hydrolase, are expected to be monomers with a preference for substrates with long lipid-like substituents of the epoxide ring. The significance of these results in the context of biological roles and industrial applications is discussed.

About this Structure

2CJP is a Single protein structure of sequence from Solanum tuberosum. Full crystallographic information is available from OCA.

Reference

X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes., Mowbray SL, Elfstrom LT, Ahlgren KM, Andersson CE, Widersten M, Protein Sci. 2006 Jul;15(7):1628-37. Epub 2006 Jun 2. PMID:16751602

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