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2vww
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vww]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VWW FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vww]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VWW FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7X2:N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5-+TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE'>7X2</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7X2:N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5-+TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE'>7X2</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bba|2bba]], [[2vx0|2vx0]], [[2vwv|2vwv]], [[2vwz|2vwz]], [[2vwy|2vwy]], [[2vx1|2vx1]], [[2vwx|2vwx]], [[2vwu|2vwu]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bba|2bba]], [[2vx0|2vx0]], [[2vwv|2vwv]], [[2vwz|2vwz]], [[2vwy|2vwy]], [[2vx1|2vx1]], [[2vwx|2vwx]], [[2vwu|2vwu]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vww RCSB], [http://www.ebi.ac.uk/pdbsum/2vww PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vww RCSB], [http://www.ebi.ac.uk/pdbsum/2vww PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EPHB4_HUMAN EPHB4_HUMAN]] Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.<ref>PMID:12734395</ref> <ref>PMID:16424904</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
| - | [[Category: Barratt, D | + | [[Category: Barratt, D]] |
| - | [[Category: Brassington, C A | + | [[Category: Brassington, C A]] |
| - | [[Category: Green, I | + | [[Category: Green, I]] |
| - | [[Category: Kettle, J G | + | [[Category: Kettle, J G]] |
| - | [[Category: Leach, A G | + | [[Category: Leach, A G]] |
| - | [[Category: Mccall, E J | + | [[Category: Mccall, E J]] |
| - | [[Category: Read, J | + | [[Category: Read, J]] |
| - | [[Category: Valentine, A L | + | [[Category: Valentine, A L]] |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
Revision as of 09:14, 25 December 2014
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
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Categories: Homo sapiens | Receptor protein-tyrosine kinase | Barratt, D | Brassington, C A | Green, I | Kettle, J G | Leach, A G | Mccall, E J | Read, J | Valentine, A L | Atp-binding | Glycoprotein | Kinase | Membrane | Mutant | Nucleotide-binding | Phosphoprotein | Receptor | Receptor tyrosine kinase | Transferase | Transmembrane | Tyrosine-protein kinase | Unphosphorylated
