3wbr
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of carbohydrate recognition domain of Blood Dendritic Cell Antigen-2 (BDCA2) lectin (crystal form-3)== | |
| - | + | <StructureSection load='3wbr' size='340' side='right' caption='[[3wbr]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3wbr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WBR FirstGlance]. <br> | |
| - | ==Function== | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wbp|3wbp]], [[3wbq|3wbq]]</td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BDCA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wbr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wbr RCSB], [http://www.ebi.ac.uk/pdbsum/3wbr PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/CLC4C_HUMAN CLC4C_HUMAN]] Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.<ref>PMID:11748283</ref> <ref>PMID:11031109</ref> | [[http://www.uniprot.org/uniprot/CLC4C_HUMAN CLC4C_HUMAN]] Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.<ref>PMID:11748283</ref> <ref>PMID:11031109</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report on crystal structures of a carbohydrate recognition domain (CRD) of human C-type lectin receptor blood dendritic cell antigen-2 (BDCA2). Three different crystal forms were obtained at 1.8-2.3 A resolution. In all three, the CRD has a basic C-type lectin fold, but a long loop extends away from the core domain to form a domain-swapped dimer. The structures of the dimers from the three different crystal forms superimpose well, indicating that domain swapping and dimer formation are energetically stable. The structure of the dimer is compared with other domain-swapped proteins, and a possible regulation mechanism of BDCA2 is discussed. Proteins 2014. (c) 2013 Wiley Periodicals, Inc. | ||
| - | + | Crystal structures of carbohydrate recognition domain of blood dendritic cell antigen-2 (BDCA2) reveal a common domain-swapped dimer.,Nagae M, Ikeda A, Kitago Y, Matsumoto N, Yamamoto K, Yamaguchi Y Proteins. 2013 Dec 27. doi: 10.1002/prot.24504. PMID:24425442<ref>PMID:24425442</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Ikeda, A | + | == References == |
| - | [[Category: Kitago, Y | + | <references/> |
| - | [[Category: Matsumoto, N | + | __TOC__ |
| - | [[Category: Nagae, M | + | </StructureSection> |
| - | [[Category: Yamaguchi, Y | + | [[Category: Human]] |
| - | [[Category: Yamamoto, K | + | [[Category: Ikeda, A]] |
| + | [[Category: Kitago, Y]] | ||
| + | [[Category: Matsumoto, N]] | ||
| + | [[Category: Nagae, M]] | ||
| + | [[Category: Yamaguchi, Y]] | ||
| + | [[Category: Yamamoto, K]] | ||
[[Category: C-type lectin fold]] | [[Category: C-type lectin fold]] | ||
[[Category: Carbohydrate binding protein]] | [[Category: Carbohydrate binding protein]] | ||
[[Category: Complex-type n-glycan]] | [[Category: Complex-type n-glycan]] | ||
[[Category: Immune receptor]] | [[Category: Immune receptor]] | ||
Revision as of 09:21, 25 December 2014
Crystal structure of carbohydrate recognition domain of Blood Dendritic Cell Antigen-2 (BDCA2) lectin (crystal form-3)
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