2cky

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[[Image:2cky.gif|left|200px]]<br /><applet load="2cky" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2cky.gif|left|200px]]
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caption="2cky, resolution 2.90&Aring;" />
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'''Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand'''<br />
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{{Structure
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|PDB= 2cky |SIZE=350|CAPTION= <scene name='initialview01'>2cky</scene>, resolution 2.90&Aring;
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|SITE= <scene name='pdbsite=AC1:Tpp+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene> and <scene name='pdbligand=TPP:THIAMINE DIPHOSPHATE'>TPP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2CKY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=OS:'>OS</scene> and <scene name='pdbligand=TPP:'>TPP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Tpp+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKY OCA].
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2CKY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKY OCA].
==Reference==
==Reference==
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Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16675665 16675665]
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Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16675665 16675665]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Ban, N.]]
[[Category: Ban, N.]]
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[[Category: nucleic acid]]
[[Category: nucleic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:49:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:16:41 2008''

Revision as of 14:16, 20 March 2008

Image:2cky.gif


PDB ID 2cky

Drag the structure with the mouse to rotate
, resolution 2.90Å
Sites:
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand


Overview

Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom-resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in complex with its natural ligand. The riboswitch specifically recognizes the TPP via conserved residues located within two highly distorted parallel "sensor" helices. The structure provides the basis for understanding the reorganization of the riboswitch fold upon TPP binding and explains the mechanism of resistance to the antibiotic pyrithiamine.

About this Structure

2CKY is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:16675665

Page seeded by OCA on Thu Mar 20 16:16:41 2008

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