2arw
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARW FirstGlance]. <br> | <table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARW FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2arw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2arw RCSB], [http://www.ebi.ac.uk/pdbsum/2arw PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2arw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2arw RCSB], [http://www.ebi.ac.uk/pdbsum/2arw PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN]] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref> Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Dingley, A J | + | [[Category: Dingley, A J]] |
| - | [[Category: Grotzinger, J | + | [[Category: Grotzinger, J]] |
| - | [[Category: Hecht, O | + | [[Category: Hecht, O]] |
| - | [[Category: Ozbek, S | + | [[Category: Ozbek, S]] |
| - | [[Category: Rose-John, S | + | [[Category: Rose-John, S]] |
| - | [[Category: Schwantner, A | + | [[Category: Schwantner, A]] |
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Fibronectin-type iii like]] | [[Category: Fibronectin-type iii like]] | ||
Revision as of 09:28, 25 December 2014
The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor
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