3a6p

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a6p RCSB], [http://www.ebi.ac.uk/pdbsum/3a6p PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a6p RCSB], [http://www.ebi.ac.uk/pdbsum/3a6p PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/XPO5_HUMAN XPO5_HUMAN]] Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.<ref>PMID:12426392</ref> <ref>PMID:11777942</ref> <ref>PMID:12426393</ref> <ref>PMID:14681208</ref> <ref>PMID:12509441</ref> <ref>PMID:14570900</ref> <ref>PMID:15254228</ref> <ref>PMID:14730017</ref> <ref>PMID:14631048</ref> <ref>PMID:15613540</ref> <ref>PMID:19124606</ref> Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP.<ref>PMID:12426392</ref> <ref>PMID:11777942</ref> <ref>PMID:12426393</ref> <ref>PMID:14681208</ref> <ref>PMID:12509441</ref> <ref>PMID:14570900</ref> <ref>PMID:15254228</ref> <ref>PMID:14730017</ref> <ref>PMID:14631048</ref> <ref>PMID:15613540</ref> <ref>PMID:19124606</ref> [[http://www.uniprot.org/uniprot/RAN_CANFA RAN_CANFA]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Katahira, J.]]
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[[Category: Katahira, J]]
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[[Category: Lee, S J.]]
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[[Category: Lee, S J]]
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[[Category: Nakagawa, A.]]
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[[Category: Nakagawa, A]]
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[[Category: Okada, C.]]
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[[Category: Okada, C]]
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[[Category: Shibata, S.]]
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[[Category: Shibata, S]]
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[[Category: Tsukihara, T.]]
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[[Category: Tsukihara, T]]
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[[Category: Yamashita, E.]]
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[[Category: Yamashita, E]]
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[[Category: Yoneda, Y.]]
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[[Category: Yoneda, Y]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Cell division]]

Revision as of 09:31, 25 December 2014

Crystal structure of Exportin-5:RanGTP:pre-miRNA complex

3a6p, resolution 2.92Å

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