1xqs
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xqs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQS FirstGlance]. <br> | <table><tr><td colspan='2'>[[1xqs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQS FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xqr|1xqr]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xqr|1xqr]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xqs RCSB], [http://www.ebi.ac.uk/pdbsum/1xqs PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xqs RCSB], [http://www.ebi.ac.uk/pdbsum/1xqs PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HPBP1_HUMAN HPBP1_HUMAN]] Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.<ref>PMID:9830037</ref> <ref>PMID:10786638</ref> <ref>PMID:12651857</ref> <ref>PMID:15215316</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bracher, A | + | [[Category: Bracher, A]] |
| - | [[Category: Brodsky, J L | + | [[Category: Brodsky, J L]] |
| - | [[Category: Chang, H C | + | [[Category: Chang, H C]] |
| - | [[Category: Dragovic, Z | + | [[Category: Dragovic, Z]] |
| - | [[Category: Guerriero, V | + | [[Category: Guerriero, V]] |
| - | [[Category: Hartl, F U | + | [[Category: Hartl, F U]] |
| - | [[Category: Shomura, Y | + | [[Category: Shomura, Y]] |
| - | [[Category: Tzvetkov, N | + | [[Category: Tzvetkov, N]] |
| - | [[Category: Young, J C | + | [[Category: Young, J C]] |
[[Category: Armadillo repeat]] | [[Category: Armadillo repeat]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Superhelical twist]] | [[Category: Superhelical twist]] | ||
Revision as of 09:32, 25 December 2014
Crystal structure of the HspBP1 core domain complexed with the fragment of Hsp70 ATPase domain
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