2x9e

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X9E FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X9E FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SVE:N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>SVE</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SVE:N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>SVE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hmo|3hmo]], [[3hmp|3hmp]], [[3h9f|3h9f]], [[3hmn|3hmn]], [[3gfw|3gfw]], [[2zmc|2zmc]], [[3cek|3cek]], [[2zmd|2zmd]], [[3dbq|3dbq]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hmo|3hmo]], [[3hmp|3hmp]], [[3h9f|3h9f]], [[3hmn|3hmn]], [[3gfw|3gfw]], [[2zmc|2zmc]], [[3cek|3cek]], [[2zmd|2zmd]], [[3dbq|3dbq]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x9e RCSB], [http://www.ebi.ac.uk/pdbsum/2x9e PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x9e RCSB], [http://www.ebi.ac.uk/pdbsum/2x9e PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Dual-specificity kinase]]
[[Category: Dual-specificity kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Avanzi, N.]]
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[[Category: Avanzi, N]]
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[[Category: Bertrand, J A.]]
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[[Category: Bertrand, J A]]
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[[Category: Bossi, R T.]]
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[[Category: Bossi, R T]]
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[[Category: Caldarelli, M.]]
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[[Category: Caldarelli, M]]
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[[Category: Cappella, P.]]
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[[Category: Cappella, P]]
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[[Category: Colombo, R.]]
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[[Category: Colombo, R]]
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[[Category: Colotta, F.]]
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[[Category: Colotta, F]]
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[[Category: Cucchi, U.]]
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[[Category: Cucchi, U]]
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[[Category: Depaolini, S R.]]
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[[Category: Depaolini, S R]]
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[[Category: Donati, D.]]
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[[Category: Donati, D]]
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[[Category: Galvani, A.]]
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[[Category: Galvani, A]]
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[[Category: Giorgini, M L.]]
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[[Category: Giorgini, M L]]
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[[Category: Isacchi, A.]]
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[[Category: Isacchi, A]]
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[[Category: Mennecozzi, M.]]
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[[Category: Mennecozzi, M]]
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[[Category: Moll, J.]]
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[[Category: Moll, J]]
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[[Category: Perrera, C.]]
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[[Category: Perrera, C]]
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[[Category: Pesenti, E.]]
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[[Category: Pesenti, E]]
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[[Category: Rusconi, L.]]
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[[Category: Rusconi, L]]
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[[Category: Sola, F.]]
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[[Category: Sola, F]]
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Mitotic checkpoint]]
[[Category: Mitotic checkpoint]]

Revision as of 09:40, 25 December 2014

HUMAN MPS1 IN COMPLEX WITH NMS-P715

2x9e, resolution 3.10Å

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