3vqu
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide== |
| + | <StructureSection load='3vqu' size='340' side='right' caption='[[3vqu]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3vqu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VQU FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=O22:4-[(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)AMINO]BENZAMIDE'>O22</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTK, MPS1, MPS1L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vqu RCSB], [http://www.ebi.ac.uk/pdbsum/3vqu PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | |
| - | == | + | == References == |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | + | ||
[[Category: Dual-specificity kinase]] | [[Category: Dual-specificity kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Daigo, Y | + | [[Category: Daigo, Y]] |
| - | [[Category: Dohi, K | + | [[Category: Dohi, K]] |
| - | [[Category: Endoh, T | + | [[Category: Endoh, T]] |
| - | [[Category: Higaki, M | + | [[Category: Higaki, M]] |
| - | [[Category: Higashino, K | + | [[Category: Higashino, K]] |
| - | [[Category: Ide, N | + | [[Category: Ide, N]] |
| - | [[Category: Iguchi, M | + | [[Category: Iguchi, M]] |
| - | [[Category: Inoue, M | + | [[Category: Inoue, M]] |
| - | [[Category: Ishioka, Y | + | [[Category: Ishioka, Y]] |
| - | [[Category: Itoh, T | + | [[Category: Itoh, T]] |
| - | [[Category: Kanazawa, T | + | [[Category: Kanazawa, T]] |
| - | [[Category: Kido, Y | + | [[Category: Kido, Y]] |
| - | [[Category: Kusakabe, K | + | [[Category: Kusakabe, K]] |
| - | [[Category: Maeda, M | + | [[Category: Maeda, M]] |
| - | [[Category: Murai, H | + | [[Category: Murai, H]] |
| - | [[Category: Nakamura, Y | + | [[Category: Nakamura, Y]] |
| - | [[Category: Okano, Y | + | [[Category: Okano, Y]] |
| - | [[Category: Sakamoto, S | + | [[Category: Sakamoto, S]] |
| - | [[Category: Sato, Y | + | [[Category: Sato, Y]] |
| - | [[Category: Shiota, T | + | [[Category: Shiota, T]] |
| - | [[Category: Tachibana, Y | + | [[Category: Tachibana, Y]] |
| - | [[Category: Tadano, G | + | [[Category: Tadano, G]] |
| - | [[Category: Tagashira, S | + | [[Category: Tagashira, S]] |
| - | [[Category: Ueda, K | + | [[Category: Ueda, K]] |
| - | [[Category: Wada, T | + | [[Category: Wada, T]] |
| - | [[Category: Yamamoto, T | + | [[Category: Yamamoto, T]] |
| - | [[Category: Yasuo, K | + | [[Category: Yasuo, K]] |
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Serine/threonine-protein kinase]] | [[Category: Serine/threonine-protein kinase]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 09:41, 25 December 2014
CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide
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Categories: Dual-specificity kinase | Homo sapiens | Daigo, Y | Dohi, K | Endoh, T | Higaki, M | Higashino, K | Ide, N | Iguchi, M | Inoue, M | Ishioka, Y | Itoh, T | Kanazawa, T | Kido, Y | Kusakabe, K | Maeda, M | Murai, H | Nakamura, Y | Okano, Y | Sakamoto, S | Sato, Y | Shiota, T | Tachibana, Y | Tadano, G | Tagashira, S | Ueda, K | Wada, T | Yamamoto, T | Yasuo, K | Kinase | Serine/threonine-protein kinase | Transferase-transferase inhibitor complex
