1zvn

From Proteopedia

(Difference between revisions)

Revision as of 09:42, 25 December 2014

Crystal structure of chick MN-cadherin EC1

Structural highlights

1zvn is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	MNcadherin (Gallus gallus)
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[CAD20_CHICK] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.^[1] ^[2] ^[3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from three type II cadherins reveals adhesive dimers formed by exchange of N-terminal beta strands between partner extracellular cadherin-1 (EC1) domains. These interfaces have two conserved tryptophan side chains that anchor each swapped strand, compared with one in type I cadherins, and include large hydrophobic regions unique to type II interfaces. The EC1 domains of type I and type II cadherins appear to encode cell adhesive specificity in vitro. Moreover, perturbation of motor neuron segregation with chimeric cadherins depends on EC1 domain identity, suggesting that this region, which includes the structurally defined adhesive interface, encodes type II cadherin functional specificity in vivo.

Type II cadherin ectodomain structures: implications for classical cadherin specificity.,Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015^[4]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Price SR, De Marco Garcia NV, Ranscht B, Jessell TM. Regulation of motor neuron pool sorting by differential expression of type II cadherins. Cell. 2002 Apr 19;109(2):205-16. PMID:12007407
↑ Shirabe K, Kimura Y, Matsuo N, Fukushima M, Yoshioka H, Tanaka H. MN-cadherin and its novel variant are transiently expressed in chick embryo spinal cord. Biochem Biophys Res Commun. 2005 Aug 19;334(1):108-16. PMID:15992777 doi:10.1016/j.bbrc.2005.06.080
↑ Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046
↑ Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zvn"

@@ Line 3: / Line 3: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1zvn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZVN FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MNcadherin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MNcadherin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zvn RCSB], [http://www.ebi.ac.uk/pdbsum/1zvn PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zvn RCSB], [http://www.ebi.ac.uk/pdbsum/1zvn PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CAD20_CHICK CAD20_CHICK]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.<ref>PMID:12007407</ref> <ref>PMID:15992777</ref> <ref>PMID:16564015</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 34: @@
 </StructureSection>
 [[Category: Gallus gallus]]
-[[Category: Bahna, F.]]
+[[Category: Bahna, F]]
-[[Category: Chen, C P.]]
+[[Category: Chen, C P]]
-[[Category: Ciatto, C.]]
+[[Category: Ciatto, C]]
-[[Category: Honig, B.]]
+[[Category: Honig, B]]
-[[Category: Jessell, T M.]]
+[[Category: Jessell, T M]]
-[[Category: Patel, S D.]]
+[[Category: Patel, S D]]
-[[Category: Price, S R.]]
+[[Category: Price, S R]]
-[[Category: Rajebhosale, M.]]
+[[Category: Rajebhosale, M]]
-[[Category: Schieren, I.]]
+[[Category: Schieren, I]]
-[[Category: Shapiro, L.]]
+[[Category: Shapiro, L]]
 [[Category: Cadherin]]
 [[Category: Cell adhesion]]

1zvn

From Proteopedia

Revision as of 09:42, 25 December 2014

Crystal structure of chick MN-cadherin EC1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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