4egl

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[[Image:4egl.jpg|left|200px]]
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==Crystal structure of two tandem RNA recognition motifs of Human antigen R==
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<StructureSection load='4egl' size='340' side='right' caption='[[4egl]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<!--
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== Structural highlights ==
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The line below this paragraph, containing "STRUCTURE_4egl", creates the "Structure Box" on the page.
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<table><tr><td colspan='2'>[[4egl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EGL FirstGlance]. <br>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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or leave the SCENE parameter empty for the default display.
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ELAVL1, HUR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4egl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4egl RCSB], [http://www.ebi.ac.uk/pdbsum/4egl PDBsum]</span></td></tr>
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{{STRUCTURE_4egl| PDB=4egl | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of two tandem RNA recognition motifs of Human antigen R===
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[[http://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN]] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4egl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGL OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, X.]]
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[[Category: Li, X]]
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[[Category: Liu, H.]]
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[[Category: Liu, H]]
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[[Category: Teng, M.]]
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[[Category: Teng, M]]
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[[Category: Wang, H.]]
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[[Category: Wang, H]]
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[[Category: Zeng, F.]]
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[[Category: Zeng, F]]
[[Category: Cytoplasm and nucleus]]
[[Category: Cytoplasm and nucleus]]
[[Category: Rna binding]]
[[Category: Rna binding]]
[[Category: Rna binding protein]]
[[Category: Rna binding protein]]
[[Category: Rrm]]
[[Category: Rrm]]

Revision as of 09:45, 25 December 2014

Crystal structure of two tandem RNA recognition motifs of Human antigen R

4egl, resolution 2.90Å

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OCA

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