2xcr

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xcr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xcr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RXV:6-METHOXY-4-(2-{4-[([1,3]OXATHIOLO[5,4-C]PYRIDIN-6-YLMETHYL)AMINO]PIPERIDIN-1-YL}ETHYL)QUINOLINE-3-CARBONITRILE'>RXV</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RXV:6-METHOXY-4-(2-{4-[([1,3]OXATHIOLO[5,4-C]PYRIDIN-6-YLMETHYL)AMINO]PIPERIDIN-1-YL}ETHYL)QUINOLINE-3-CARBONITRILE'>RXV</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xcs|2xcs]], [[2xct|2xct]], [[2xco|2xco]], [[2xcq|2xcq]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xcs|2xcs]], [[2xct|2xct]], [[2xco|2xco]], [[2xcq|2xcq]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xcr RCSB], [http://www.ebi.ac.uk/pdbsum/2xcr PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xcr RCSB], [http://www.ebi.ac.uk/pdbsum/2xcr PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Bax, B D.]]
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[[Category: Bax, B D]]
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[[Category: Brown, K K.]]
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[[Category: Brown, K K]]
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[[Category: Chan, P F.]]
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[[Category: Chan, P F]]
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[[Category: Eggleston, D S.]]
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[[Category: Eggleston, D S]]
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[[Category: Fosberry, A.]]
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[[Category: Fosberry, A]]
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[[Category: Gentry, D R.]]
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[[Category: Gentry, D R]]
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[[Category: Giordano, I.]]
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[[Category: Giordano, I]]
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[[Category: Gorrec, F.]]
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[[Category: Gorrec, F]]
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[[Category: Gwynn, M N.]]
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[[Category: Gwynn, M N]]
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[[Category: Hann, M M.]]
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[[Category: Hann, M M]]
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[[Category: Hennessy, A.]]
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[[Category: Hennessy, A]]
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[[Category: Hibbs, M.]]
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[[Category: Hibbs, M]]
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[[Category: Huang, J.]]
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[[Category: Huang, J]]
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[[Category: Jones, E.]]
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[[Category: Jones, E]]
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[[Category: Jones, J.]]
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[[Category: Jones, J]]
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[[Category: Lewis, C J.]]
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[[Category: Lewis, C J]]
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[[Category: May, E W.]]
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[[Category: May, E W]]
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[[Category: Pearson, N D.]]
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[[Category: Pearson, N D]]
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[[Category: Shen, C.]]
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[[Category: Shen, C]]
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[[Category: Shillings, A.]]
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[[Category: Shillings, A]]
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[[Category: Singh, O.]]
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[[Category: Singh, O]]
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[[Category: Spitzfaden, C.]]
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[[Category: Spitzfaden, C]]
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[[Category: Theobald, A F.]]
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[[Category: Theobald, A F]]
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[[Category: Wohlkonig, A.]]
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[[Category: Wohlkonig, A]]
[[Category: Isomerase]]
[[Category: Isomerase]]

Revision as of 09:57, 25 December 2014

THE 3.5A CRYSTAL STRUCTURE OF THE CATALYTIC CORE (B'A' REGION) OF STAPHYLOCOCCUS AUREUS DNA GYRASE COMPLEXED WITH GSK299423 AND DNA

2xcr, resolution 3.50Å

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OCA

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