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3fxk
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fxk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fxk RCSB], [http://www.ebi.ac.uk/pdbsum/3fxk PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fxk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fxk RCSB], [http://www.ebi.ac.uk/pdbsum/3fxk PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN]] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Protein phosphatase|Protein phosphatase]] | *[[Protein phosphatase|Protein phosphatase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:03, 25 December 2014
Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 10 mM of Mn2+
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