3mcf
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mcf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mcf RCSB], [http://www.ebi.ac.uk/pdbsum/3mcf PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mcf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mcf RCSB], [http://www.ebi.ac.uk/pdbsum/3mcf PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NUD10_HUMAN NUD10_HUMAN]] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 10:04, 25 December 2014
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha
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Categories: Homo sapiens | Arrowsmith, C H | Berg, S van der | Berglund, H | Bountra, C | Collins, R | Edwards, A M | Flodin, S | Flores, A | Graslund, S | Hammarstrom, M | Johansson, I | Karlberg, T | Kol, S | Kotenyova, T | Moche, M | Nordlund, P | Nyman, T | Persson, C | Structural genomic | Schuler, H | Schutz, P | Siponen, M I | Thorsell, A G | Tresaugues, L | Wahlberg, E | Weigelt, J | Welin, M | Wisniewska, M | Aps2 | Diphosphoinositol pentakisphosphate | Dipp3a | Hydrolase | Metal-binding | Nudix | Nudt10 | Sgc | Sgc stockholm | Signal transduction
