3n7j
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7j RCSB], [http://www.ebi.ac.uk/pdbsum/3n7j PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7j RCSB], [http://www.ebi.ac.uk/pdbsum/3n7j PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BXD_CLOBO BXD_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '60-Lys-|-Leu-61' bond of synaptobrevins-1 and -2. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 10:08, 25 December 2014
Crystal structure of botulinum neurotoxin serotype D binding domain
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