3gn4
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3gn4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GN4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3gn4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GN4 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MYO6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa]), Cam, CG8472 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MYO6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa]), Cam, CG8472 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gn4 RCSB], [http://www.ebi.ac.uk/pdbsum/3gn4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gn4 RCSB], [http://www.ebi.ac.uk/pdbsum/3gn4 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[http://www.uniprot.org/uniprot/CALM_DROME CALM_DROME]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Calmodulin|Calmodulin]] | ||
*[[Myosin|Myosin]] | *[[Myosin|Myosin]] | ||
== References == | == References == | ||
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[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Franzini-Armstrong, C | + | [[Category: Franzini-Armstrong, C]] |
| - | [[Category: Houdusse, A | + | [[Category: Houdusse, A]] |
| - | [[Category: Kim, H | + | [[Category: Kim, H]] |
| - | [[Category: Llinas, P | + | [[Category: Llinas, P]] |
| - | [[Category: Menetrey, J | + | [[Category: Menetrey, J]] |
| - | [[Category: Mukherjea, M | + | [[Category: Mukherjea, M]] |
| - | [[Category: Safer, D | + | [[Category: Safer, D]] |
| - | [[Category: Selvin, P R | + | [[Category: Selvin, P R]] |
| - | [[Category: Sweeney, H L | + | [[Category: Sweeney, H L]] |
| - | [[Category: Travaglia, M | + | [[Category: Travaglia, M]] |
| - | [[Category: Zong, A B | + | [[Category: Zong, A B]] |
[[Category: 3-helix bundle]] | [[Category: 3-helix bundle]] | ||
[[Category: Actin-binding]] | [[Category: Actin-binding]] | ||
Revision as of 10:11, 25 December 2014
Myosin lever arm
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Categories: Drosophila melanogaster | Sus scrofa | Franzini-Armstrong, C | Houdusse, A | Kim, H | Llinas, P | Menetrey, J | Mukherjea, M | Safer, D | Selvin, P R | Sweeney, H L | Travaglia, M | Zong, A B | 3-helix bundle | Actin-binding | Atp-binding | Calmodulin-binding | Endocytosis | Golgi apparatus | Hearing | Lever arm | Membrane | Motility | Motor protein | Motor protein-metal binding protein complex | Myosin | Nucleotide-binding | Nucleus | Phosphoprotein | Protein transport | Transport | Unconventional myosin
