4my2

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{{STRUCTURE_4my2| PDB=4my2 | SCENE= }}
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==Crystal Structure of Norrin in fusion with Maltose Binding Protein==
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===Crystal Structure of Norrin in fusion with Maltose Binding Protein===
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<StructureSection load='4my2' size='340' side='right' caption='[[4my2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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{{ABSTRACT_PUBMED_24186977}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4my2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MY2 FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">malE, Z5632, ECs5017, NDP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4my2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4my2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4my2 RCSB], [http://www.ebi.ac.uk/pdbsum/4my2 PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Norrin is a cysteine-rich growth factor that is required for angiogenesis in the eye, ear, brain, and female reproductive organs. It functions as an atypical Wnt ligand by specifically binding to the Frizzled 4 (Fz4) receptor. Here we report the crystal structure of Norrin, which reveals a unique dimeric structure with each monomer adopting a conserved cystine knot fold. Functional studies demonstrate that the novel Norrin dimer interface is required for Fz4 activation. Furthermore, we demonstrate that Norrin contains separate binding sites for Fz4 and for the Wnt ligand coreceptor Lrp5 (low-density lipoprotein-related protein 5) or Lrp6. Instead of inducing Fz4 dimerization, Norrin induces the formation of a ternary complex with Fz4 and Lrp5/6 by binding to their respective extracellular domains. These results provide crucial insights into the assembly and activation of the Norrin-Fz4-Lrp5/6 signaling complex.
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==About this Structure==
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Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.,Ke J, Harikumar KG, Erice C, Chen C, Gu X, Wang L, Parker N, Cheng Z, Xu W, Williams BO, Melcher K, Miller LJ, Xu HE Genes Dev. 2013 Nov 1;27(21):2305-19. doi: 10.1101/gad.228544.113. PMID:24186977<ref>PMID:24186977</ref>
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[[4my2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY2 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024186977</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Eco57]]
[[Category: Eco57]]
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[[Category: Chen, C.]]
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[[Category: Chen, C]]
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[[Category: Gu, X.]]
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[[Category: Gu, X]]
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[[Category: Jurecky, C.]]
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[[Category: Jurecky, C]]
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[[Category: Ke, J.]]
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[[Category: Ke, J]]
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[[Category: Melcher, K.]]
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[[Category: Melcher, K]]
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[[Category: Parker, N.]]
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[[Category: Parker, N]]
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[[Category: Williams, B O.]]
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[[Category: Williams, B O]]
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[[Category: Xu, H E.]]
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[[Category: Xu, H E]]
[[Category: Angiogenesis]]
[[Category: Angiogenesis]]
[[Category: Cysteine-rich protein]]
[[Category: Cysteine-rich protein]]

Revision as of 10:15, 25 December 2014

Crystal Structure of Norrin in fusion with Maltose Binding Protein

4my2, resolution 2.40Å

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