2ctn
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2ctn.jpg|left|200px]] | + | [[Image:2ctn.jpg|left|200px]] |
| - | + | ||
| - | '''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES''' | + | {{Structure |
| + | |PDB= 2ctn |SIZE=350|CAPTION= <scene name='initialview01'>2ctn</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= CTNC(A-CYS) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]) | ||
| + | }} | ||
| + | |||
| + | '''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2CTN is a [ | + | 2CTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTN OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain., Sia SK, Li MX, Spyracopoulos L, Gagne SM, Liu W, Putkey JA, Sykes BD, J Biol Chem. 1997 Jul 18;272(29):18216-21. PMID:[http:// | + | Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain., Sia SK, Li MX, Spyracopoulos L, Gagne SM, Liu W, Putkey JA, Sykes BD, J Biol Chem. 1997 Jul 18;272(29):18216-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9218458 9218458] |
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 26: | Line 35: | ||
[[Category: regulatory]] | [[Category: regulatory]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:19:42 2008'' |
Revision as of 14:19, 20 March 2008
| |||||||
| Ligands: | |||||||
| Gene: | CTNC(A-CYS) (Gallus gallus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES
Overview
The regulation of cardiac muscle contraction must differ from that of skeletal muscles to effect different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator of cardiac muscle contraction, possesses different functional and Ca2+-binding properties compared with skeletal TnC and features a Ca2+-binding site I, which is naturally inactive. The structure of cardiac TnC in the Ca2+-saturated state has been determined by nuclear magnetic resonance spectroscopy. The regulatory domain exists in a "closed" conformation even in the Ca2+-bound (the "on") state, in contrast to all predicted models and differing significantly from the calcium-induced structure observed in skeletal TnC. This structure in the Ca2+-bound state, and its subsequent interaction with troponin I (TnI), are crucial in determining the specific regulatory mechanism for cardiac muscle contraction. Further, it will allow for an understanding of the action of calcium-sensitizing drugs, which bind to cardiac TnC and are known to enhance the ability of cardiac TnC to activate cardiac muscle contraction.
About this Structure
2CTN is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
Reference
Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain., Sia SK, Li MX, Spyracopoulos L, Gagne SM, Liu W, Putkey JA, Sykes BD, J Biol Chem. 1997 Jul 18;272(29):18216-21. PMID:9218458
Page seeded by OCA on Thu Mar 20 16:19:42 2008
Categories: Gallus gallus | Single protein | Gagne, S M. | Li, M X. | Liu, W. | Putkey, J A. | Sia, S K. | Spyracopoulos, L. | Sykes, B D. | CA | Calcium-binding protein | Cardiac | Muscle | Regulatory
