3qjn
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [http://www.ebi.ac.uk/pdbsum/3qjn PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qjn RCSB], [http://www.ebi.ac.uk/pdbsum/3qjn PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT]] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 10:30, 25 December 2014
Structural flexibility of Shank PDZ domain is important for its binding to different ligands
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