2i61
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2i61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I61 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2i61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I61 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CO2:CARBON+DIOXIDE'>CO2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i61 RCSB], [http://www.ebi.ac.uk/pdbsum/2i61 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i61 RCSB], [http://www.ebi.ac.uk/pdbsum/2i61 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIX2_LEIQH SIX2_LEIQH]] Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects.<ref>PMID:9275012</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Leiurus quinquestriatus hebraeus]] | [[Category: Leiurus quinquestriatus hebraeus]] | ||
| - | [[Category: Frolow, F | + | [[Category: Frolow, F]] |
| - | [[Category: Gordon, D | + | [[Category: Gordon, D]] |
| - | [[Category: Gurevitz, M | + | [[Category: Gurevitz, M]] |
| - | [[Category: Karbat, I | + | [[Category: Karbat, I]] |
| - | [[Category: Turkov, M | + | [[Category: Turkov, M]] |
[[Category: Anti-insect]] | [[Category: Anti-insect]] | ||
[[Category: Depressant]] | [[Category: Depressant]] | ||
Revision as of 10:32, 25 December 2014
Depressant anti-insect neurotoxin, LqhIT2 from Leiurus quinquestriatus hebraeus
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