2ybu
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ybu RCSB], [http://www.ebi.ac.uk/pdbsum/2ybu PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ybu RCSB], [http://www.ebi.ac.uk/pdbsum/2ybu PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CHIA_HUMAN CHIA_HUMAN]] Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.<ref>PMID:11085997</ref> <ref>PMID:18824549</ref> <ref>PMID:19342690</ref> <ref>PMID:19435888</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Chitinase|Chitinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Chitinase]] | [[Category: Chitinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Aalten, D Van | + | [[Category: Aalten, D Van]] |
| - | [[Category: Allen, J E | + | [[Category: Allen, J E]] |
| - | [[Category: Andersen, O A | + | [[Category: Andersen, O A]] |
| - | [[Category: Betou, M | + | [[Category: Betou, M]] |
| - | [[Category: Eggleston, I M | + | [[Category: Eggleston, I M]] |
| - | [[Category: Maizels, R M | + | [[Category: Maizels, R M]] |
| - | [[Category: Sutherland, T E | + | [[Category: Sutherland, T E]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 10:38, 25 December 2014
CRYSTAL STRUCTURE OF HUMAN ACIDIC CHITINASE IN COMPLEX WITH BISDIONIN F
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