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2cy6

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[[Image:2cy6.gif|left|200px]]<br /><applet load="2cy6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2cy6.gif|left|200px]]
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caption="2cy6, resolution 2.00&Aring;" />
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'''Crystal structure of ConM in complex with trehalose and maltose'''<br />
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{{Structure
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|PDB= 2cy6 |SIZE=350|CAPTION= <scene name='initialview01'>2cy6</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of ConM in complex with trehalose and maltose'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2CY6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=TRE:'>TRE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY6 OCA].
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2CY6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY6 OCA].
==Reference==
==Reference==
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Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins., Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF Jr, Cavada BS, J Struct Biol. 2006 Jun;154(3):280-6. Epub 2006 Apr 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16677825 16677825]
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Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins., Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF Jr, Cavada BS, J Struct Biol. 2006 Jun;154(3):280-6. Epub 2006 Apr 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16677825 16677825]
[[Category: Canavalia maritima]]
[[Category: Canavalia maritima]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: x-ray diffraction]]
[[Category: x-ray diffraction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:53:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:21:09 2008''

Revision as of 14:21, 20 March 2008

Image:2cy6.gif


PDB ID 2cy6

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Crystal structure of ConM in complex with trehalose and maltose


Overview

The crystal structure of Canavalia maritima lectin (ConM) complexed with trehalose and maltose revealed relevant point mutations in ConA-like lectins. ConM with the disaccharides and other ConA-like lectins complexed with carbohydrates demonstrated significant differences in the position of H-bonds. The main difference in the ConM structure is the replacement of Pro202 by Ser202, a residue that promotes the approximation of Tyr12 to the carbohydrate-binding site. The O-6' of the second glucose ring in maltose interacts with Tyr12, while in trehalose the interaction is established by the O-2' and Tyr12, explaining the higher affinity of ConM for disaccharides compared to monosaccharides.

About this Structure

2CY6 is a Protein complex structure of sequences from Canavalia maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins., Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF Jr, Cavada BS, J Struct Biol. 2006 Jun;154(3):280-6. Epub 2006 Apr 21. PMID:16677825

Page seeded by OCA on Thu Mar 20 16:21:09 2008

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