4fwz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:4fwz.png|left|200px]]
+
==Aquoferric CuB myoglobin (L29H F43H sperm whale myoglobin)==
 +
<StructureSection load='4fwz' size='340' side='right' caption='[[4fwz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4fwz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FWZ FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
 +
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fwx|4fwx]], [[4fwy|4fwy]]</td></tr>
 +
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9755 Physeter catodon])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fwz RCSB], [http://www.ebi.ac.uk/pdbsum/4fwz PDBsum]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
No spare Tyr: Rational design of functional enzymes with a high number of turnovers is a challenge, especially those with a complex active site, such as respiratory oxidases. Introducing two His and one Tyr residues into myoglobin resulted in enzymes that reduce O(2) to H(2) O with more than 1000 turnovers (red line, see scheme) and minimal release of reactive oxygen species. The positioning of the Tyr residue is critical for activity.
-
{{STRUCTURE_4fwz| PDB=4fwz | SCENE= }}
+
A Designed Functional Metalloenzyme that Reduces O(2) to H(2) O with Over One Thousand Turnovers.,Miner KD, Mukherjee A, Gao YG, Null EL, Petrik ID, Zhao X, Yeung N, Robinson H, Lu Y Angew Chem Int Ed Engl. 2012 Jun 4;51(23):5589-92. doi: 10.1002/anie.201201981., Epub 2012 Apr 26. PMID:22539151<ref>PMID:22539151</ref>
-
===Aquoferric CuB myoglobin (L29H F43H sperm whale myoglobin)===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
-
 
+
==See Also==
-
==About this Structure==
+
*[[Myoglobin|Myoglobin]]
-
[[4fwz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWZ OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:022539151</ref><references group="xtra"/>
+
</StructureSection>
[[Category: Physeter catodon]]
[[Category: Physeter catodon]]
-
[[Category: Gao, Y G.]]
+
[[Category: Gao, Y G]]
-
[[Category: Lu, Y.]]
+
[[Category: Lu, Y]]
-
[[Category: Miner, K D.]]
+
[[Category: Miner, K D]]
-
[[Category: Petrik, I D.]]
+
[[Category: Petrik, I D]]
-
[[Category: Robinson, H.]]
+
[[Category: Robinson, H]]
[[Category: Globin]]
[[Category: Globin]]
[[Category: Oxidase]]
[[Category: Oxidase]]
[[Category: Transport protein]]
[[Category: Transport protein]]

Revision as of 10:54, 25 December 2014

Aquoferric CuB myoglobin (L29H F43H sperm whale myoglobin)

4fwz, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fwz"
Personal tools