3n46
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n46 RCSB], [http://www.ebi.ac.uk/pdbsum/3n46 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n46 RCSB], [http://www.ebi.ac.uk/pdbsum/3n46 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 10:55, 25 December 2014
Human FPPS complex with NOV_980 and zoledronic acid/MG2+
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