2cyx
From Proteopedia
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| - | [[Image:2cyx.gif|left|200px]] | + | [[Image:2cyx.gif|left|200px]] |
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| - | '''Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)''' | + | {{Structure |
| + | |PDB= 2cyx |SIZE=350|CAPTION= <scene name='initialview01'>2cyx</scene>, resolution 2.56Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] | ||
| + | |GENE= UBE2G2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2CYX is a [ | + | 2CYX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYX OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)., Arai R, Yoshikawa S, Murayama K, Imai Y, Takahashi R, Shirouzu M, Yokoyama S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):330-4. Epub 2006 Mar 25. PMID:[http:// | + | Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)., Arai R, Yoshikawa S, Murayama K, Imai Y, Takahashi R, Shirouzu M, Yokoyama S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):330-4. Epub 2006 Mar 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16582478 16582478] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Yoshikawa, S.]] | [[Category: Yoshikawa, S.]] | ||
[[Category: ligase]] | [[Category: ligase]] | ||
| - | [[Category: national project on protein structural and functional | + | [[Category: national project on protein structural and functional analyse]] |
[[Category: nppsfa]] | [[Category: nppsfa]] | ||
[[Category: riken structural genomics/proteomics initiative]] | [[Category: riken structural genomics/proteomics initiative]] | ||
[[Category: rsgi]] | [[Category: rsgi]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: ubiquitin-conjugating enzyme (e2)]] | [[Category: ubiquitin-conjugating enzyme (e2)]] | ||
[[Category: ubl conjugation pathway]] | [[Category: ubl conjugation pathway]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:21:19 2008'' |
Revision as of 14:21, 20 March 2008
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| , resolution 2.56Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | UBE2G2 (Homo sapiens) | ||||||
| Activity: | Ubiquitin--protein ligase, with EC number 6.3.2.19 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)
Overview
The human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7) is involved in protein degradation, including a process known as endoplasmic reticulum-associated degradation (ERAD). The crystal structure of human UBE2G2/UBC7 was solved at 2.56 angstroms resolution. The UBE2G2 structure comprises a single domain consisting of an antiparallel beta-sheet with four strands, five alpha-helices and two 3(10)-helices. Structural comparison of human UBE2G2 with yeast Ubc7 indicated that the overall structures are similar except for the long loop region and the C-terminal helix. Superimposition of UBE2G2 on UbcH7 in a c-Cbl-UbcH7-ZAP70 ternary complex suggested that the two loop regions of UBE2G2 interact with the RING domain in a similar way to UbcH7. In addition, the extra loop region of UBE2G2 may interact with the RING domain or its neighbouring region and may be involved in the binding specificity and stability.
About this Structure
2CYX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)., Arai R, Yoshikawa S, Murayama K, Imai Y, Takahashi R, Shirouzu M, Yokoyama S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):330-4. Epub 2006 Mar 25. PMID:16582478
Page seeded by OCA on Thu Mar 20 16:21:19 2008
Categories: Homo sapiens | Single protein | Ubiquitin--protein ligase | Arai, R. | Imai, Y. | Murayama, K. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Shirouzu, M. | Takahashi, R. | Yokoyama, S. | Yoshikawa, S. | Ligase | National project on protein structural and functional analyse | Nppsfa | Riken structural genomics/proteomics initiative | Rsgi | Structural genomic | Ubiquitin-conjugating enzyme (e2) | Ubl conjugation pathway
