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2g9a

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[[Image:2g9a.png|left|200px]]
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==Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5==
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<StructureSection load='2g9a' size='340' side='right' caption='[[2g9a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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{{STRUCTURE_2g9a| PDB=2g9a | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9A FirstGlance]. <br>
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===Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5===
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2g99|2g99]]</td></tr>
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{{ABSTRACT_PUBMED_016600877}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [http://www.ebi.ac.uk/pdbsum/2g9a PDBsum]</span></td></tr>
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</table>
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==About this Structure==
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== Function ==
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[[2g9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA].
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[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/2g9a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Histone|Histone]]
*[[Histone|Histone]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016600877</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chai, J.]]
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[[Category: Chai, J]]
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[[Category: Han, Z.]]
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[[Category: Han, Z]]
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[[Category: Shen, Y.]]
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[[Category: Shen, Y]]
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[[Category: Wang, H.]]
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[[Category: Wang, H]]
[[Category: Structural protein-dna binding protein complex]]
[[Category: Structural protein-dna binding protein complex]]
[[Category: Wd40 repeat protein]]
[[Category: Wd40 repeat protein]]

Revision as of 10:58, 25 December 2014

Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5

2g9a, resolution 2.70Å

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